IL1A and psoriasis: Systemic sclerotic changes of the large arteries represent aberrant remodeling of the vascular walls with aortic stenosis and the deterioration of peripheral circulation mimics human arteriosclerosis obliterans, which were partially ameliorated by the simultaneous treatment with neutralizing antibodies against IL-1 α⁄β [14], leading to the new concept of “inflammatory skin march” for psoriasis and atopic dermatitis [15].