Seltzer et al. and Emadi et al. [74,129] reported that bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl) ethyl sulfide (BPTES), an inhibitor of glutaminase, selectively suppresses tumor growth in IDH mutant glioma and AML by targeting the fragile glutamine metabolism. The gene discussed is IDH2; the disease is acute myeloid leukemia.