Recently, an exome sequencing screening in EGFR-mutated gliomas identified multiple cooperating partner genes that are associated with EGFR driving gliomagenesis, including Cdkn2a, Nf1, Spred1, and Nav3. However, IDH mutations are not associated with EGFR, suggesting no cooperation between these two genes during gliomagenesis [44]. This evidence concerns the gene IDH2 and central nervous system cancer.