Furthermore, studies suggest that Orai1 can also functionally couple with other channels when promoting migration, with Orai1 in colon cancer cells forming part of a functional channel complex with small conductance Ca2+-activated potassium channel 3 (SK3) and TRPC1 channels to amplify SOCE, AKT activation, and migratory behaviour [213]. This evidence concerns the gene ORAI1 and colonic neoplasm.