Elevated TRPC5 expression has been identified in colon tumours and metastases, where it is correlated with poor prognosis [201]; TRPC5 overexpression in colon cancer cells led to altered intracellular Ca2+ levels, decreased E-cadherin, and promotion of EMT, resulting in increased proliferation and invasion [202]. The gene discussed is TRPC5; the disease is malignant colon neoplasm.