ORAI1 and neoplasm: Interestingly, collagen I (a factor found in the tumour microenvironment) regulates colocalization of Orai1 and the Kv10.1 channel in breast cancer cells to enhance Ca2+ entry and cell survival [214,215], indicating that extracellular matrix factors within the tumour microenvironment can influence ion channel functional coupling to remodel SOCE in cancer cells.