SH-SY5Y cells were treated with 1-methyl-4-phenylpyridinium (MPP+) or doxycycline for two in vitro PD models, displaying TUDCA’s antioxidant qualities in both by preventing ROS production and lipid peroxidation through increased nuclear factor erythroid 2 related factor 2 (Nrf2) expression. This evidence concerns the gene NFE2L2 and Parkinson disease.