Combinations of genetic mutations (i.e., mutant variants of genes Peripherin or retinal pigment epithelium (RPE)65), morphological changes of the retinal pigment epithelium (RPE) and photoreceptor dysfunction (i.e., photoreceptor-specific transcription factor CRX) contribute to multiple degenerative retina diseases: glaucoma, retinitis pigmentosa (RP), age-related macular degeneration (AMD) and inherited retinal degeneration (RD). The gene discussed is CRX; the disease is age-related macular degeneration.