STUB1 and coronary artery disorder: A subsequent analysis of four case–control studies that included 4726 participants with coronary heart disease and 3529 controls confirmed this association and showed a risk of coronary heart disease for carriers of CHIP that was 1.9 times greater than in non-carriers (95% confidence interval 1.4 to 2.7) for individuals matched for traditional cardiovascular risk factors, including age, sex, type 2 diabetes status, and smoking history [8].