AGO2 and melanoma: Using a cell lysate of the melanoma cell line MZ-Mel2, the in vitro transcribed TAP1 3′ UTR, but not the MS2 control RNA nor the amylose resin beads loaded with MS2BP-MBP, specifically co-purified the RNA-induced silencing complex component argonaute 2 (AGO2) suggesting a putative posttranscriptional regulation of TAP1 expression by a binding of miRs (Figure 2a).