Although further studies are required to provide more mechanistic insights into the link between miR-21-3p and miR-26b-5p high expression, HLA class I antigen presentation and CTL recognition, miR-21-3p/miR-26b-5phigh TAP1low expression levels appear to be associated with a reduced CD8+ T cell infiltrate and a more aggressive behavior of primary melanomas. Here, CD8A is linked to melanoma.