Methylation of several genes, i.e., COMT (catechol-O-methyltransferase), SLC2A9, SLC38A4, and SLC6A5 (solute carrier family 2, 38A, and 6A members), KIF26A (kinesin family member 26A), and CGRP might be associated with migraine, while specific diets addressing these alterations might work the opposite way and prevent migraine attacks [125]. The gene discussed is COMT; the disease is migraine disorder.