Furthermore, experimental studies showed that TNF and IL1β, which are released from endothelial cells during viral infection, are able to activate endothelial cells via NFκB pathway, which finally induces the new genes expression associated with the inflammatory response, i.e., adhesion molecules like vascular cell adhesion protein 1 (VCAM-1) and intracellular adhesion molecule 1 (ICAM-1) [55]. This evidence concerns the gene TNF and viral infectious disease.