In AR-negative PCa cells, C-1311 significantly downregulated the expression of the key glycolytic enzymes PGK1, GPI, PPI1, PGAM1, ALDOA, and ALDOC. These results suggest that C-1311, by targeting glycolysis, may promote metabolic stress in androgen-independent PCa cells. The gene discussed is PGAM1; the disease is posterior cortical atrophy.