Moreover, C-1311 also decreased expression of direct AR target genes that play a functional role in HR, including CHEK1, RAD54L, RAD54B, POLE2, and XRCC2. Downregulation of HR in response to the inhibition of the AR by enzalutamide has been shown to sensitize PCa cells to PARP inhibitors [52]. The gene discussed is POLE2; the disease is posterior cortical atrophy.