Given that sensitive markers of fibrinolytic enhancement, such as plasma levels of D-dimer and plasmin-α2-plasmin inhibitor complex (PIC), are elevated in SSc patients [51,52,53,54], the altered balance of coagulation/fibrinolysis system appears to cause a variable degree of luminal thrombosis following vascular injury, contributing to impaired peripheral circulation, the induction of inflammation and the subsequent activation of vascular cells (endothelial cells and pericytes/vascular smooth muscle cells) and fibroblasts [55,56,57]. Here, PLG is linked to systemic sclerosis.