TGFB1 and systemic sclerosis: The expression profile of the three isoforms of TGF-β is recognized as follows in SSc: (i) all the three isoforms of TGF-β are detectable in ECM, and (ii) the expression of TGF-β1 and TGF-β2 is most prominent around dermal vessels, and is associated with perivascular infiltrating mononuclear cells [94,95,96].