We demonstrated the down-regulation of a large number of genes involved in T cell activation, lymphocyte activation and immune response and the down-regulation of genes previously reported to induce immune suppression in NB, including CADM1, CCL19, CCL2, CCR7, CD226, and CXCL12 [58,59,60,63,65,66]. The gene discussed is CXCL12; the disease is neuroblastoma.