The implementation of CoMPaS and the corresponding software tool offers fascinating prospects for personalized diagnostics and early treatment by detecting the earliest diagnostic period of sdMTSs in BC patients (T1-3N0-3M0 and ER/PR/HER2/Ki-67 subtypes) with regard to the eighth edition AJCC prognostic staging system for breast cancer and the growth rate of the PT and sdMTSs in BC [22,23,24,25,26,69,70,71,72,101,102,103,104,105,106]. Here, ESR1 is linked to breast cancer.