ESR1 and breast cancer: The TVDT, which helped in the development of the mathematical growth model, is a combined quality indicator that reflects the subtype of BC, the proliferative activity, the degree of tumor differentiation, the Nottingham prognostic index (NPI) score, receptor activity (ER(+), ER(−), PR(+), PR(−), HER2(+), HER2(−), Ki-67), and triple-negative BC [47,48,49,50,51,52,53,54,63,64,65,66,67,68,69,70,71,72,90,91,92,93,94,95,96,97,98,99,100].