PPARG and Alzheimer disease: However, activation of PPARγ using both agonists: Pioglitazone and DSP-8658, also overexpresses the scavenger receptor CR36 and, while doing so, enhances microglial phagocytosis of Amyloid-β (Aβ) in primary microglial cell culture and in vivo using a mouse model of Alzheimer’s Disease (AD) [95].