Indeed, in RA patients on anti-TNF-α therapy after 3 months, the TNFR1 36 A/A genotype was associated with a worse DAS-based European League Against Rheumatism (EULAR) response than A/G or G/G genotype to (p = 0.04) [14]. This evidence concerns the gene TNFRSF1A and rheumatoid arthritis.