To further study the participation of P2X7R in the epithelial-to-mesenchymal transition (EMT), we assessed the effect of stimulating 4T1 cancer cells with BzATP on the expression of genes associated with the mesenchymal (SNAI1, ZEB1, TWIST) or the epithelial (ZO1, CDH1) phenotypes. The gene discussed is CDH1; the disease is cancer.