The diagnosis of LCH is determined by conventional histology along with the immunohistochemical staining for CD1a and Langerin (CD207); the latter is the most recent introduced monoclonal antibody for LCH diagnosis, as highly specific and sensitive protein needed for formation of the Birbeck–Broadbent granules [1,2,3,5]. This evidence concerns the gene CD1A and Langerhans cell histiocytosis.