In mice with syngeneic transplants of mammary duct carcinomas, the α2-AR agonists clonidine and dexmedetomidine enhanced tumor growth, which was inhibited by yohimbine and rauwolscine; in the absence of clonidine, rauwolscine reduced tumor growth, with yohimbine having a smaller and inconclusive effect [98]. The gene discussed is ADORA2A; the disease is neoplasm.