PPARG and acute myeloid leukemia: On the other hand, Sanchez et al. observed that RXR agonist bexarotene in combination with liver X receptor (LXR) agonists (T0901317 or GW3965), but not PPAR-γ ligand rosiglitazone, induced potent differentiation and cytotoxicity in THP-1 cells and primary cells from AML patients [74].