Using a CML cell line (K-562) and leukemia stem cells (LSCs) from CML patients, Prost et al. demonstrated that adding PPAR-γ agonist pioglitazone to TKIs significantly decreased the clonogenic potential of CML cells through downregulating the expression of signal transducer and activator of transcription 5 (STAT5) and its target genes [95]. This evidence concerns the gene PPARG and chronic myelogenous leukemia, BCR-ABL1 positive.