We reported that the Mt1 gene is suppressed in P1798 mouse lymphosarcoma cells, but long-term cadmium (Cd) exposure (0.1 μM, 7days) and subsequent short-term exposure to high Cd concentrations (10 μM, 3 hr) decreases MT1 DNA methylation and induces the Mt1 gene [26]. Here, MT1A is linked to lymphoma.