We do know that upregulation of DRD1, DRD3, and DRD5 expression in blood, along with alterations in the expression of other dopaminergic signaling genes, has been associated with lower resilience to stressful events and other psychological parameters, including personality, depression, anxiety, and intelligence, in age, sex, and race-matched individuals [11]. The gene discussed is DRD1; the disease is major depressive disorder.