Conversely, downregulation of decorin and lymph node metastasis independently predicted poor prognosis in oral squamous cell carcinomas [46]; DCN expression in osteosarcoma cells blocked their metastatic spread to the lungs [47]; and virus-mediated decorin delivery inhibited the growth of breast cancer and suppressed metastasis formation in various organs [48,49,50,51]. This evidence concerns the gene DCN and osteosarcoma.