IGFBP7 and acute kidney injury: Recently, Göcze et al. performed a randomized trial in critically ill patients after major noncardiac surgery and reported that early implementation of KDIGO prevention bundle triggered by biomarker detection (TIMP2 × IGFBP7) significantly reduced the incidence of moderate and severe AKI (6.7% vs. 19.7%, p = 0.04; OR 3.43, 95% CI 1.04–11.32) [37].