Immunohistochemical analysis of tissues from breast cancer patients shows that inflammatory stroma, which expresses higher LPA3, is more likely to have a higher histological grade, and more frequent estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) positivity, which, overall, is associated with a worse phenotype [96]. The gene discussed is ESR1; the disease is breast cancer.