The coexisting expression of PTTG1 and PTTG2 genes with the PTTG3P pseudogene may suggest that PTTG3P regulates PTTG1 and PTTG2. It is possible that PTTG3P positively promotes the regulation of parental genes PTTG1 and PTTG2, as is the case in esophageal squamous cell carcinoma [16]. The gene discussed is PTTG2; the disease is esophageal squamous cell carcinoma.