At gene level, AA women with breast cancer showed higher expression of several key cell cycle regulating genes, including CCNE2, CCNB1, CCNA1, CDKN2A and other tumor related genes CRYBB2, TMPO, AMFR, PSPHL, which directly impact the development and aggressiveness of tumors. The gene discussed is PSPHP1; the disease is breast carcinoma.