MMP2 and age-related macular degeneration: Although angiotensin II (Ang II) is able to increase MMP-2 activity and MMP-14 via ERK and p38 in RPE cells, thus inducing changes in the BM which may lead to an increase in subretinal deposits [208], and the use of ARBs can induce regression of choroidal neovascularization in animal models [222,223], recent studies have suggested that these medications do not seem to provide a protective effect against the development of choroidal neovascularization in patients with AMD [224,225].