It is possible that its connection with AMD could be as much by inhibiting the transforming growth factor-b [177], which is seen as an important regulator of extracellular matrix deposition and angiogenesis, as by the digestion of fibronectin-producing fragments, which has been reported to increase the secretion of IL-6, MCP-1, MMP-3, and MMP-9 in murine EPR [178]. The gene discussed is MMP3; the disease is age-related macular degeneration.