TIMP3 and age-related macular degeneration: One of the most relevant clinical examples of TIMP-3 dysfunction and the accumulation of increased levels of TIMP-3 in the BM may be patients with Sorsby’s fundus dystrophy (SFD), a rare autosomal dominant disease with striking similarities to AMD, especially in the late stages, where macular dystrophy, drusen-like deposits, and CNV are primarily seen, and may be misdiagnosed as AMD [181].