YBX1 and melanoma: Accordingly, upon downregulation of intracellular YB-1 levels by means of RNA interference (Figure S7) or CRISPR/Cas9 mediated YBX1 knockout (Figure S8), we found an impaired wound closure capacity for several melanoma cell lines (A375, MelJuso, WM115, WM266-4) (Figure 5a,b; Figure S9a,b).