TWIST1 and neoplasm: In this context, cytoplasmic YB-1 has been shown to promote the translation of mRNAs encoding both epithelial-to-mesenchymal transition (EMT)-regulating (e.g., Snail, Twist, Zeb2/Sip1) and cytoprotective factors facilitating tumour cell metastasis [37,39,40,41,42].