Gattinoni et al., demonstrated that the induction of the wnt-beta-cantenin (WNT-β catenin) signalling pathway during expansion by inhibitors of glycogen synthase kinase-3beta (GSK3β) blocked T-cell differentiation and promoted the generation of self-renewing TSCM cells with an enhanced proliferative and anti-tumour capacity [115]. This evidence concerns the gene GSK3B and neoplasm.