TSH promotes the TG hepatocyte up-take and endorse liver steatosis through binding to TSH receptor, which sets the hepatic sterol regulatory element-binding transcription factor 1 SREBP-1c activity via the cyclic AMP (cAMP)/protein kinase A(PKA)/peroxisome proliferator-activated receptor-α (PPARα) (cAMP/PKA/PPARα) pathway, paralleling with decreased AMPK function and subsequently raised lipogenesis. The gene discussed is PPARA; the disease is fatty liver disease.