Whereas many of these pathways were related to the intermediary metabolism, there were also significant positives in signaling processes associated to the proteasome, mTOR, Hedgehog, p53, NOTCH, adipokine, PPAR, phosphoinositol, VEGF, and TGFβ signaling, peroxisome and hypertrophic cardiomyopathy. Here, TGFB1 is linked to hypertrophic cardiomyopathy.