They demonstrated the involvement of d-2HG in the inhibition of hepatocellular differentiation and uncontrolled proliferation of liver progenitor cells, with cooperative function of activated KRas, establishing that IDH1mut may represent an early event in iCCA carcinogenesis, as observed in glioblastoma and acute myeloid leukemia (AML). Here, KRAS is linked to acute myeloid leukemia.