PLOD1 and cancer: Additionally, in IDH1mut cancers, collagen maturation defects were observed due to the 2HG-mediated hindrance to α-KG-dependent prolyl 4-hydroxylases 1, 2, and 3 (P4HA1/2/3), and procollagen-lysine 2-oxoglutarate 5-dioxygenases 1, 2, and 3 (PLOD1/2/3) activity [99].