CDKN2A and cancer: Although it is not just a peculiarity of this cancer type, genes interested by epigenetic silencing are tumor suppressors involved in cell cycle control (e.g., P16INK4A, P14ARF and RASSF1A), regulation of cell adhesion/attachment and signaling (e.g., CDH1, APC and SOCS3), redox homeostasis (e.g., GSTP), and regulation of DNA damage (e.g., MLH-1) [28].