To determine whether estimated glomerular filtration rate (eGFR) calculated using P-cystatin C is lower compared to eGFR calculated using creatinine, the eGFR was quantified and the kinetics for both eGFR compared in Figure 1H. The eGFRcystatin c was significantly lower than eGFRcreatinine in the first week following HFRS onset (0–4 and 5–7 DPDO). Here, CST3 is linked to hemorrhagic fever with renal syndrome.