It is still poorly understood how these TXNIP functions in immune cells affect metabolic phenotypes in TXNIP-WKO, while interestingly, we have previously found that lipopolysaccharide (LPS) injection in TXNIP-WKO unexpectedly exhibited dysregulation of the lipid and glucose metabolisms, such as hyperinsulinemia, hypoglycemia, fat deposition in the liver and kidney, organ injuries, glycogen depletion, and elevation of serum lipid derivatives such as free fatty acids, triglycerides, and cholesterol [46,47]. Here, TXNIP is linked to Hyperinsulinemia.