For example, TXNIP expression is inversely correlated with hematopoietic malignancies, such as adult T-cell leukemia (ATL), and its responsiveness to glucocorticoids to induce apoptosis in T-cell lines infected with human T lymphotropic virus type-I (HTLV-I), the causative virus of adult T cell leukemia (ATL) [20,21]. This evidence concerns the gene TXNIP and adult T-cell leukemia/lymphoma.