Although TXNIP-NLRP3 inflammasome axis is independent with known NLRP3 activation by oligomers of islet amyloid polypeptides (IAPP) [49] (a protein that forms amyloid deposits that has been observed during type-2 diabetes in pancreatic β cells), TXNIP-NLRP3 inflammasome axis seems to be an important regulator for specific tissue inflammation in redox dependent and independent manners [48,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. The gene discussed is IAPP; the disease is type 2 diabetes mellitus.