Thioredoxin interacting protein (TXNIP) was first cloned as an up-regulated gene by 1,25-dihydroxy D3 (Vitamin D3) and named as Vitamin D3 upregulated protein 1 (VDUP1) in the human leukemia cell line (HL-60) derived from a patient with promyelocytic leukemia [1]. This evidence concerns the gene TXNIP and acute promyelocytic leukemia.