Experimental diabetes models induced by STZ, or polygenic models of obesity, adult onset T2D, diet-induced hyperglycemia and obesity, and NONcNZO10/LtJ mice all have MBH TXNIP expression increased at feeding status, suggesting that TXNIP is responsible for the nutritional sensing and pathophysiological conditions in MBH [103]. Here, TXNIP is linked to obesity due to melanocortin 4 receptor deficiency.