NFKB1 and cancer: UA derivatives containing three carbons as the side chain at the C-3 position of UA were synthesized in stereoisomeric forms using the Barbier–Grignard method and (Compounds 30 and 31, Table 5) were found to be effective against all three cancer cell lines; these compounds inhibited cell growth and induced the inhibition of NF-κB activation in the cell lines [167].