The majority of these studies emphasize the appearance of CSC phenotype (e.g., CD44, CD133, aldehyde dehydrogenase 1 and leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) expression) and functions (e.g., chemoresistance, sphere formation, growth, and metastatic spread) as a result of EV-based communication between CAFs and cancer cells (Table 1). Here, LGR5 is linked to cancer.