In line with present observations, (Figure 4) HDM/DNCB stimulation upregulated the T-bet, STAT3, and GATA3 and other allergy mediating cytokines (IL-4, IL-5, IL-10, IL-13, and IFN-γ) and chemokine (TARC) expression levels, while these were dose-dependently downregulated following SHE treatment. The gene discussed is IL4; the disease is allergic disease.