The Na+, K+-ATPase–ECS interaction leads to changes in the membrane electrical potential, and the activation of mitogen-activated protein kinase (ERK, or MAPK), protein kinase B (AKT), and nuclear factor kappa-light-chain-enhancer (NFκB) [19,71], which modifies neuronal activity and neurotransmission that, in turn, participate in the regulation of behavior and BD. This evidence concerns the gene AKT1 and Behcet disease.