With respect to the inflammation and immune system, PDA patients showed a significant increase in CD3+, CD4+, and CD8+ T lymphocyte proportions, and a decreased B lymphocyte proportion after effective paroxetine treatment and, in the same disorder, a change in the lymphocyte proliferative response to phytohemagglutinin correlated with a reduction in self-reported anxiety level after treatment [265]. The gene discussed is CD4; the disease is Anxiety.