Kim and colleagues [258] found that baseline peripheral lymphocyte subsets did not differ between PDA patients and HCs but, after paroxetine treatment (with a significant reduction in different psychometric scales), PDA patients showed a significant increase in the CD3+, CD4+, and CD8+ T lymphocyte proportions, and a decreased B lymphocyte proportion. The gene discussed is CD8A; the disease is Patent ductus arteriosus.