in serum [27] and mucosal spermine oxidase (but exclusively in inflammatory cells; E.C. 1.5.3.16) [28], COX2 (E.C. 1.14.99.1) [29], NOX2 (E.C. 1.6.3.1) [29], and NOS2(E.C. 1.14.13.39) [29,30] have been unanimously elevated in IBD. The gene discussed is NOS2; the disease is irritable bowel syndrome.