T-cell factors/lymphoid enhancer–binding factor (TCF/LEF) family comprising TCF7, TCF7L1, TCF7 L2 and LEF1 are essential cofactors for activation of the Wnt downstream target genes, and the aberrant expression of TCF/LEF family has been implicated in the process of GC tumorigenesis [14]. The gene discussed is LEF1; the disease is gastric cancer.