Interestingly, the GSEA analysis of these patient-derived organoids revealed that genes related to hallmark_Wnt_beta-catenin-signaling and cell proliferation such as hallmark_E2F_targets, hallmark_G2M_checkpoint, hallmark_MYC targets_V1, and hallmark_MYC targets_V2 were highly enriched in the 2,4-DAQ-sensitive tumor organoids versus the 2,4-DAQ-resistant tumor organoids. Here, MYC is linked to neoplasm.