VEGFA and breast cancer: For example, nanoparticles composed of PEG and mannose doubly modified trimethyl chitosan and citraconic anhydride-grafted poly (allylamine hydrochloride) (PC) have been developed for the delivery of siRNAs against the vascular endothelial growth factor (VEGF) and placental growth factor (PIGF) to breast cancer cells and M2-TAMs (Figure 4g).