With regard to advanced GC (Table 3), patients with SRC were younger and more likely to be female and had more tumors located in the middle stomach, more scirrhous stromal reactions, a more infiltrating type, fewer MSI-H tumors, more PIK3CA amplifications, less PD-L1 expression, fewer ARID1A mutations and more advanced TNM stages than those without SRC. Here, PIK3CA is linked to gastric cancer.