In TB patients treated with antimycobacterial agents, there were both a significant increase in serologic Th1 markers ((sLAG)-3) accompanied by a decrease in Th2 markers (IgE, soluble CD30, and CCL22/macrophage-derived chemokine) when compared to healthy controls at both 2–3 months and 6-month time points. The gene discussed is CCL22; the disease is tuberculosis.