In our current study, we evaluated the neuroprotective effects of pretreated PYC originating from the maritime pine bark in the CA1 area of gerbil hippocampus following TFI using histochemistry with CV, immunohistochemistry with NeuN, and histofluorescence with F-J B. It was reported that PYC protected neuronal pheochromocytoma (PC)12 cells from hydrogen peroxide-induced injury in vitro [37]. This evidence concerns the gene RBFOX3 and hereditary pheochromocytoma-paraganglioma.