Moreover, the high levels of IL-6 in plasma positively corelate with insulin resistance [54] and are explained by different mechanisms: the suppression of lipoprotein lipase and reduction of triglycerides levels in plasma [55], the activation of suppressor cytokine signaling proteins (SOCS) and blocking of STAT5B-mediated of the transcription factor activation for the insulin receptor [56,57]. Here, CISH is linked to Insulin resistance.