The introduction of immunotherapy with Programmed Death 1, Programmed Death-Ligand 1 (PD-1 or PD-L1) or Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) immune checkpoint inhibitors has deeply transformed the management of many cancers, leading to remarkable improvements in terms of survival and radiological response for some patients [1]. This evidence concerns the gene CD274 and cancer.