Animals were also subjected to an open-chest model of myocardial infarction and cardiac damage was compared between wild-type, Kcnma1-/- (global knockout), CM-Kcnma1-Crefl/fl,, and SM-Kcnma1-Crefl/fl (conditional mutant lacking Kcnma1 from smooth muscle) [47]. The gene discussed is KCNMA1; the disease is myocardial infarction.