Immunohistochemical analysis of gastric cancer tissues revealed that IQGAP3 accumulated in the cytoplasm of 23 (88.5%) of 26 gastric adenocarcinomas examined (Figure 1D); positive staining was observed in 19 of 21 intestinal-type tumors, and in 4 of 5 diffuse-type tumors. The gene discussed is IQGAP3; the disease is gastric cancer.