Matrigel invasion assay showed that MKN1 and TMK1 cells treated with si-IQGAP3 had fewer invading cells than the cells treated with control siRNA (0.17- and 0.31-fold decrease in the number of invading cells compared to control; p = 0.001 and 0.033, respectively; a two-tailed Student’s t-test), indicating that inhibition of IQGAP3 could suppress invasion of gastric cancer cells (Figure 5A). This evidence concerns the gene IQGAP3 and gastric cancer.