Shi and colleagues have shown that epithelial-mesenchymal transition (EMT) markers including e-cadherin, fibronectin, vimentin, n-cadherin are overexpressed in HCC cells with up-regulation of IQGAP3, while knockdown of IQGAP3 showed the reduction of the above markers [45]. The gene discussed is VIM; the disease is hepatocellular carcinoma.