We recently reported that PM01183, at higher doses, affects the inflammatory tumor milieu via a direct cytotoxic effect on mononuclear phagocytes, whereas at lower doses it affects the adhesion and migration of monocytes, limiting their production of pro-inflammatory cytokines, such as IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1) [21]. The gene discussed is CCL2; the disease is neoplasm.