The relationship between GSK-3β, total tau, p-Tau 181 levels, Aβ and neurodegeneration, investigated mostly in cases with mild cognitive dysfunction [107,108] or mild AD, reflects a robust negative correlation between abnormal proteins concentrations with the Mini Mental State Exam and Wechsler Memory Scale-I and a positive one with Tower of London test [109]. This evidence concerns the gene GSK3B and Alzheimer disease.