MAPT and Alzheimer disease: Jin et al. [152] in a clearance of brain-derived Aβ study found that peritoneal dialysis, a clinically existing therapeutic method for CKD, significantly reduced Aβ deposition, also attenuating other AD-type pathologies, such as neuroinflammation, tau hyperphosphorylation, glial activation, synaptic dysfunction, and neuronal loss and attenuated the behavioral impairment in APPswe/PS1 mice.