Other recognized risk factors include family history [6], degeneration or vascular dysfunction [7,8], obesity [9], hypotension or hypertension [10], diabetes [11,12,13], hyperlipidemia [14,15], low levels of education, physical inactivity [16], and the existence of epsilon 4 allele of the apolipoprotein E gene (ApoE4) [6,17]. This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.