The potential mechanisms of kidney–brain crosstalk regarding inflammatory molecules are based on the fact that cytokines, such as IL-1β, interleukine-6 (IL-6), the TNF, and transforming growth factor β (TGF-β) frequently involved in the pathogenesis of CKD, may influence remote organs, such as the brain, reinforcing the idea of a kidney–brain inflammatory crosstalk [40,76]. This evidence concerns the gene IL6 and chronic kidney disease.